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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CCDC146
All Species:
9.09
Human Site:
Y508
Identified Species:
25
UniProt:
Q8IYE0
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYE0
NP_065930.2
955
112806
Y508
K
K
K
K
C
E
I
Y
R
R
L
R
E
F
A
Chimpanzee
Pan troglodytes
XP_519167
955
112923
Y508
K
K
K
K
C
E
I
Y
R
R
L
R
E
F
A
Rhesus Macaque
Macaca mulatta
XP_001083560
850
101055
Y464
K
K
K
K
C
E
I
Y
R
R
L
K
E
F
A
Dog
Lupus familis
XP_852499
956
112901
H509
K
K
K
K
R
E
I
H
R
R
L
K
E
F
A
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Q66H60
974
114627
H527
R
K
R
K
R
E
I
H
R
R
L
K
E
F
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507522
927
109406
H481
K
K
K
K
C
E
I
H
K
R
L
K
E
F
A
Chicken
Gallus gallus
XP_415968
920
107917
H473
K
K
R
K
R
R
V
H
K
Q
L
Q
G
V
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001076522
860
100875
E425
S
E
A
D
I
L
L
E
R
R
K
D
L
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794541
712
83971
E371
L
Q
L
K
V
A
N
E
G
V
A
H
T
Q
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
86.1
87.5
N.A.
N.A.
76.2
N.A.
67.6
47.3
N.A.
35.5
N.A.
N.A.
N.A.
N.A.
32.7
Protein Similarity:
100
99.7
88
94.7
N.A.
N.A.
89.6
N.A.
82.8
69.5
N.A.
58.4
N.A.
N.A.
N.A.
N.A.
50.5
P-Site Identity:
100
100
93.3
80
N.A.
N.A.
66.6
N.A.
80
33.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
N.A.
93.3
N.A.
100
73.3
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
0
0
12
0
0
0
0
12
0
0
0
78
% A
% Cys:
0
0
0
0
45
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
12
0
0
0
0
0
0
0
12
0
0
0
% D
% Glu:
0
12
0
0
0
67
0
23
0
0
0
0
67
12
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
0
% F
% Gly:
0
0
0
0
0
0
0
0
12
0
0
0
12
0
0
% G
% His:
0
0
0
0
0
0
0
45
0
0
0
12
0
0
0
% H
% Ile:
0
0
0
0
12
0
67
0
0
0
0
0
0
0
0
% I
% Lys:
67
78
56
89
0
0
0
0
23
0
12
45
0
0
12
% K
% Leu:
12
0
12
0
0
12
12
0
0
0
78
0
12
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
12
0
0
0
0
0
0
0
12
0
12
0
12
0
% Q
% Arg:
12
0
23
0
34
12
0
0
67
78
0
23
0
0
0
% R
% Ser:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
12
% T
% Val:
0
0
0
0
12
0
12
0
0
12
0
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
34
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _